273938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5363711..5364306 Replicon chromosome
Accession NZ_CP119298
Organism Pseudomonas aeruginosa strain SNDPR-01

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PZ484_RS24950 Protein ID WP_003117425.1
Coordinates 5364028..5364306 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PZ484_RS24945 Protein ID WP_003099268.1
Coordinates 5363711..5364016 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ484_RS24910 5358851..5359699 + 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PZ484_RS24920 5359866..5360807 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PZ484_RS24925 5360924..5361538 + 615 WP_031806327.1 50S ribosomal protein L25/general stress protein Ctc -
PZ484_RS24930 5361580..5362164 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PZ484_RS24935 5362205..5363305 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PZ484_RS24945 5363711..5364016 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PZ484_RS24950 5364028..5364306 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PZ484_RS24955 5364359..5364483 - 125 Protein_4929 integrase -
PZ484_RS24960 5364631..5366859 + 2229 WP_003113525.1 TonB-dependent receptor -
PZ484_RS24965 5366929..5367576 - 648 WP_003095021.1 carbonate dehydratase -
PZ484_RS24970 5367683..5368876 - 1194 WP_213870760.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T273938 WP_003117425.1 NZ_CP119298:c5364306-5364028 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT273938 WP_003099268.1 NZ_CP119298:c5364016-5363711 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References