Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 46718..46971 | Replicon | plasmid p4 |
Accession | NZ_CP119178 | ||
Organism | Klebsiella pneumoniae strain X-CRHVKP-130 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | PY995_RS27420 | Protein ID | WP_001312851.1 |
Coordinates | 46822..46971 (+) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | srnC | ||
Locus tag | - | ||
Coordinates | 46718..46777 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PY995_RS27380 (41975) | 41975..42439 | + | 465 | Protein_51 | DUF4158 domain-containing protein | - |
PY995_RS27385 (42496) | 42496..43200 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
PY995_RS27390 (43225) | 43225..43425 | + | 201 | WP_072354025.1 | hypothetical protein | - |
PY995_RS27395 (43445) | 43445..44191 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
PY995_RS27400 (44246) | 44246..44806 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
PY995_RS27405 (44938) | 44938..45138 | + | 201 | WP_015059022.1 | hypothetical protein | - |
PY995_RS27410 (45524) | 45524..46123 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
PY995_RS27415 (46185) | 46185..46517 | + | 333 | WP_152916585.1 | hypothetical protein | - |
- (46718) | 46718..46777 | - | 60 | NuclAT_0 | - | Antitoxin |
- (46718) | 46718..46777 | - | 60 | NuclAT_0 | - | Antitoxin |
- (46718) | 46718..46777 | - | 60 | NuclAT_0 | - | Antitoxin |
- (46718) | 46718..46777 | - | 60 | NuclAT_0 | - | Antitoxin |
PY995_RS27420 (46822) | 46822..46971 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
PY995_RS27425 (47255) | 47255..47503 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
PY995_RS27430 (47748) | 47748..47822 | + | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
PY995_RS27435 (47815) | 47815..48672 | + | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
PY995_RS27440 (48940) | 48940..49593 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
PY995_RS27445 (49686) | 49686..49943 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
PY995_RS27450 (49876) | 49876..50277 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
PY995_RS27455 (50526) | 50526..50941 | + | 416 | Protein_66 | IS1-like element IS1B family transposase | - |
PY995_RS27460 (50977) | 50977..51522 | - | 546 | Protein_67 | Tn3 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | cmlA1 / qacE / blaCTX-M-14 / blaKPC-2 / blaTEM-1B | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..232058 | 232058 | |
- | inside | IScluster/Tn | cmlA1 / qacE / blaCTX-M-14 / blaKPC-2 / blaTEM-1B | - | 31..43200 | 43169 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T273901 WP_001312851.1 NZ_CP119178:46822-46971 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
Antitoxin
Download Length: 60 bp
>AT273901 NZ_CP119178:c46777-46718 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|