Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 369459..370125 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P0S03_RS01770 Protein ID WP_172750178.1
Coordinates 369808..370125 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag P0S03_RS01765 Protein ID WP_003837894.1
Coordinates 369459..369755 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS01750 (366635) 366635..367108 - 474 WP_283903385.1 transcription elongation factor GreB -
P0S03_RS01755 (367334) 367334..368053 + 720 WP_001157751.1 two-component system response regulator OmpR -
P0S03_RS01760 (368050) 368050..369402 + 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
P0S03_RS01765 (369459) 369459..369755 - 297 WP_003837894.1 NadS family protein Antitoxin
P0S03_RS01770 (369808) 369808..370125 - 318 WP_172750178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0S03_RS01775 (370248) 370248..371870 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
P0S03_RS01780 (372249) 372249..373967 + 1719 WP_172750179.1 DUF4153 domain-containing protein -
P0S03_RS01785 (374077) 374077..374955 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12238.14 Da        Isoelectric Point: 10.0909

>T273870 WP_172750178.1 NZ_CP119165:c370125-369808 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDNIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT273870 WP_003837894.1 NZ_CP119165:c369755-369459 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References