Detailed information of TA system TA273857

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 493984..494241
• Replicon: chromosome
• Accession: NZ_CP119159
• Organism: Enterococcus faecalis strain GENOMIC22-006

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: P0D81_RS02465
• Protein ID: WP_021164441.1
• Coordinates: 493984..494085 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	494034..494241 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P0D81_RS02450	490418..490918	-	501	WP_002378961.1	cysteine hydrolase family protein	-
P0D81_RS02455	491089..493359	+	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
P0D81_RS02460	493550..493651	+	102	WP_021164442.1	putative holin-like toxin	-
P0D81_RS02465	493984..494085	+	102	WP_021164441.1	putative holin-like toxin	Toxin
-	494034..494241	-	208	-	-	Antitoxin
P0D81_RS02470	494267..494719	-	453	WP_002378959.1	YueI family protein	-
P0D81_RS02475	494904..495851	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
P0D81_RS02480	495848..496813	+	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
P0D81_RS02485	496810..497565	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
P0D81_RS02490	497604..498557	+	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T273857 WP_021164441.1 NZ_CP119159:493984-494085 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT273857 NZ_CP119159:c494241-494034 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin