Detailed information of TA system TA273847

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 315647..316045
• Replicon: chromosome
• Accession: NZ_CP119159
• Organism: Enterococcus faecalis strain GENOMIC22-006

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: P0D81_RS01620
• Protein ID: WP_002387585.1
• Coordinates: 315647..315790 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	315901..316045 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P0D81_RS01615	312398..315457	+	3060	WP_002387586.1	WxL domain-containing protein	-
P0D81_RS01620	315647..315790	-	144	WP_002387585.1	putative holin-like toxin	Toxin
-	315901..316045	+	145	-	-	Antitoxin
P0D81_RS01625	316386..320144	+	3759	WP_010706868.1	WxL domain-containing protein	-
P0D81_RS01630	320334..320438	-	105	WP_021164545.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T273847 WP_002387585.1 NZ_CP119159:c315790-315647 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 145 bp

>AT273847 NZ_CP119159:315901-316045 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGC

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin