Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 146424..146959 Replicon plasmid pCFSAN126950_01
Accession NZ_CP119151
Organism Enterococcus faecium strain GENOMIC22-005

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag P0D82_RS15100 Protein ID WP_002314366.1
Coordinates 146424..146696 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag P0D82_RS15105 Protein ID WP_002297422.1
Coordinates 146696..146959 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D82_RS15065 (P0D82_15065) 142370..142642 - 273 WP_230201796.1 hypothetical protein -
P0D82_RS15070 (P0D82_15070) 142741..143421 - 681 WP_044383156.1 IS6-like element ISS1N family transposase -
P0D82_RS15075 (P0D82_15075) 143630..143791 - 162 WP_002349958.1 hypothetical protein -
P0D82_RS15080 (P0D82_15080) 144051..144599 - 549 WP_002292681.1 hypothetical protein -
P0D82_RS15085 (P0D82_15085) 144600..145457 - 858 WP_002292680.1 ParA family protein -
P0D82_RS15090 (P0D82_15090) 145741..146028 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
P0D82_RS15095 (P0D82_15095) 146018..146347 - 330 WP_002292678.1 AbrB family transcriptional regulator -
P0D82_RS15100 (P0D82_15100) 146424..146696 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
P0D82_RS15105 (P0D82_15105) 146696..146959 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P0D82_RS15110 (P0D82_15110) 147193..148101 + 909 Protein_170 IS982-like element ISEfm1 family transposase -
P0D82_RS15115 (P0D82_15115) 148104..149279 - 1176 WP_002336205.1 MFS transporter -
P0D82_RS15120 (P0D82_15120) 149282..151531 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199975 199975
- inside IScluster/Tn - - 142741..157560 14819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T273842 WP_002314366.1 NZ_CP119151:c146696-146424 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT273842 WP_002297422.1 NZ_CP119151:c146959-146696 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References