273837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4522366..4523066 Replicon chromosome
Accession NZ_CP119143
Organism Streptomyces sp. VNUA24

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PYR72_RS19045 Protein ID WP_275456450.1
Coordinates 4522366..4522752 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYR72_RS19050 Protein ID WP_275456451.1
Coordinates 4522749..4523066 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR72_RS19020 (PYR72_19020) 4517692..4519446 + 1755 WP_275456447.1 succinate dehydrogenase flavoprotein subunit -
PYR72_RS19025 (PYR72_19025) 4519446..4520207 + 762 WP_013001271.1 succinate dehydrogenase iron-sulfur subunit -
PYR72_RS19030 (PYR72_19030) 4520409..4520672 - 264 WP_013001272.1 TM2 domain-containing protein -
PYR72_RS19035 (PYR72_19035) 4521010..4521408 - 399 WP_275456448.1 DUF2752 domain-containing protein -
PYR72_RS19040 (PYR72_19040) 4521401..4521895 - 495 WP_275456449.1 TM2 domain-containing protein -
PYR72_RS19045 (PYR72_19045) 4522366..4522752 + 387 WP_275456450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYR72_RS19050 (PYR72_19050) 4522749..4523066 + 318 WP_275456451.1 helix-turn-helix transcriptional regulator Antitoxin
PYR72_RS19055 (PYR72_19055) 4523154..4523939 + 786 WP_275456452.1 hypothetical protein -
PYR72_RS19060 (PYR72_19060) 4524302..4524538 - 237 WP_275456453.1 hypothetical protein -
PYR72_RS19065 (PYR72_19065) 4525101..4525529 - 429 WP_275456454.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-92)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14897.96 Da        Isoelectric Point: 8.6697

>T273837 WP_275456450.1 NZ_CP119143:4522366-4522752 [Streptomyces sp. VNUA24]
MTWHLEMTGDVRDWLHRLRKDDRVSARLVGQAIQALVEEGPDLGRPLVDRIKGSALHHLKELRPGSTGDSEIRILFAFDP
ERSAVLLVAGDKAGRWTAWYRHAMPLAEERYTEWLDHLARRRHKETER

Download         Length: 387 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11805.25 Da        Isoelectric Point: 4.6896

>AT273837 WP_275456451.1 NZ_CP119143:4522749-4523066 [Streptomyces sp. VNUA24]
MTSFHSWDEVKEEVYDTEDLDEIMAGARRMVAEARAHRLAEMRRELGLTQREVADRMHVRQERVSAIERGKTESAEVGTV
AAYVEALGGELEIVANFNGTRVVVA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References