Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4137489..4138288 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PYZ88_RS20140 Protein ID WP_000347251.1
Coordinates 4137824..4138288 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PYZ88_RS20135 Protein ID WP_001307405.1
Coordinates 4137489..4137824 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS20120 (4133274) 4133274..4134044 - 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -
PYZ88_RS20125 (4134060) 4134060..4135394 - 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
PYZ88_RS20130 (4135769) 4135769..4137340 + 1572 WP_001273761.1 galactarate dehydratase -
PYZ88_RS20135 (4137489) 4137489..4137824 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PYZ88_RS20140 (4137824) 4137824..4138288 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PYZ88_RS20145 (4138343) 4138343..4139152 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PYZ88_RS20150 (4139401) 4139401..4140681 + 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
PYZ88_RS20155 (4140704) 4140704..4141177 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PYZ88_RS20160 (4141188) 4141188..4141967 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PYZ88_RS20165 (4141957) 4141957..4142835 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PYZ88_RS20170 (4142853) 4142853..4143287 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4126614..4138288 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T273795 WP_000347251.1 NZ_CP119120:4137824-4138288 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT273795 WP_001307405.1 NZ_CP119120:4137489-4137824 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References