Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4023279..4023972 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag PYZ88_RS19585 Protein ID WP_000415585.1
Coordinates 4023676..4023972 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PYZ88_RS19580 Protein ID WP_000650107.1
Coordinates 4023279..4023674 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS19570 (4019143) 4019143..4021401 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
PYZ88_RS19575 (4021539) 4021539..4023146 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
PYZ88_RS19580 (4023279) 4023279..4023674 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PYZ88_RS19585 (4023676) 4023676..4023972 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
PYZ88_RS19590 (4024177) 4024177..4024659 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PYZ88_RS19595 (4024712) 4024712..4025104 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PYZ88_RS19600 (4025256) 4025256..4025915 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
PYZ88_RS19605 (4025912) 4025912..4027261 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
PYZ88_RS19610 (4027307) 4027307..4027639 - 333 WP_000914690.1 DUF2645 family protein -
PYZ88_RS19615 (4027646) 4027646..4028356 - 711 WP_000834030.1 hypothetical protein -
PYZ88_RS19620 (4028359) 4028359..4028838 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T273794 WP_000415585.1 NZ_CP119120:c4023972-4023676 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT273794 WP_000650107.1 NZ_CP119120:c4023674-4023279 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References