Detailed information of TA system TA273769

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 386338..386917
• Replicon: chromosome
• Accession: NZ_CP119113
• Organism: Staphylococcus aureus strain GENOMIC22-002

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: PXV46_RS01760
• Protein ID: WP_001025401.1
• Coordinates: 386338..386583 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	386552..386917 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PXV46_RS01710 (PXV46_01710)	381834..382448	+	615	WP_000191466.1	hypothetical protein	-
PXV46_RS01715 (PXV46_01715)	382445..382591	-	147	WP_001013104.1	hypothetical protein	-
PXV46_RS01720 (PXV46_01720)	382627..382809	-	183	WP_000705240.1	hypothetical protein	-
PXV46_RS01725 (PXV46_01725)	382905..383825	-	921	WP_031903415.1	exonuclease domain-containing protein	-
PXV46_RS01730 (PXV46_01730)	383841..384455	-	615	WP_000801423.1	XRE family transcriptional regulator	-
PXV46_RS01735 (PXV46_01735)	384627..384854	+	228	WP_031903416.1	hypothetical protein	-
PXV46_RS01740 (PXV46_01740)	384880..385656	+	777	WP_001148559.1	phage antirepressor	-
PXV46_RS01745 (PXV46_01745)	385672..385890	+	219	WP_001001383.1	hypothetical protein	-
PXV46_RS01750 (PXV46_01750)	385940..386083	+	144	WP_000939498.1	hypothetical protein	-
PXV46_RS01755 (PXV46_01755)	386073..386282	-	210	WP_000642492.1	hypothetical protein	-
PXV46_RS01760 (PXV46_01760)	386338..386583	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
PXV46_RS01765 (PXV46_01765)	386552..386917	-	366	WP_016170627.1	hypothetical protein	Antitoxin
PXV46_RS01770 (PXV46_01770)	386973..387686	+	714	WP_058332268.1	BRO family protein	-
PXV46_RS01775 (PXV46_01775)	387699..387908	+	210	WP_000455728.1	hypothetical protein	-
PXV46_RS01780 (PXV46_01780)	387922..388092	+	171	WP_031838382.1	DUF1270 domain-containing protein	-
PXV46_RS01785 (PXV46_01785)	388097..388411	+	315	WP_031838381.1	hypothetical protein	-
PXV46_RS01790 (PXV46_01790)	388476..388778	+	303	WP_031838380.1	DUF2482 family protein	-
PXV46_RS01795 (PXV46_01795)	388783..389043	+	261	WP_000291481.1	DUF1108 family protein	-
PXV46_RS01800 (PXV46_01800)	389056..389592	+	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
PXV46_RS01805 (PXV46_01805)	389593..390372	+	780	WP_000137071.1	ATP-binding protein	-
PXV46_RS01810 (PXV46_01810)	390402..390956	+	555	WP_000704713.1	single-stranded DNA-binding protein	-
PXV46_RS01815 (PXV46_01815)	390969..391640	+	672	WP_031838379.1	putative HNHc nuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	380503..426417	45914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T273769 WP_001025401.1 NZ_CP119113:386338-386583 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT273769 NZ_CP119113:c386917-386552 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin