Detailed information of TA system TA273766

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2616230..2616809
• Replicon: chromosome
• Accession: NZ_CP119109
• Organism: Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: PXV45_RS13255
• Protein ID: WP_001025401.1
• Coordinates: 2616564..2616809 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2616230..2616595 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PXV45_RS13215 (2612972)	2612972..2613529	-	558	WP_000645049.1	DUF2815 family protein	-
PXV45_RS13220 (2613556)	2613556..2614722	-	1167	WP_031794996.1	DUF2800 domain-containing protein	-
PXV45_RS13225 (2614719)	2614719..2615081	-	363	WP_000985976.1	hypothetical protein	-
PXV45_RS13230 (2615096)	2615096..2615419	-	324	WP_000174994.1	hypothetical protein	-
PXV45_RS13235 (2615498)	2615498..2615659	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
PXV45_RS13240 (2615672)	2615672..2615935	-	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
PXV45_RS13245 (2615960)	2615960..2616175	-	216	WP_001097552.1	hypothetical protein	-
PXV45_RS13250 (2616230)	2616230..2616595	+	366	WP_016170627.1	hypothetical protein	Antitoxin
PXV45_RS13255 (2616564)	2616564..2616809	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
PXV45_RS13260 (2616865)	2616865..2617074	+	210	WP_000642492.1	hypothetical protein	-
PXV45_RS13265 (2617064)	2617064..2617207	-	144	WP_000939498.1	hypothetical protein	-
PXV45_RS13270 (2617236)	2617236..2618012	-	777	WP_001148544.1	Rha family transcriptional regulator	-
PXV45_RS13275 (2618026)	2618026..2618262	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
PXV45_RS13280 (2618414)	2618414..2618728	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
PXV45_RS13285 (2618741)	2618741..2619202	+	462	WP_000525004.1	hypothetical protein	-
PXV45_RS13290 (2619220)	2619220..2619804	+	585	WP_031918390.1	hypothetical protein	-
PXV45_RS13295 (2620035)	2620035..2620181	+	147	WP_074370993.1	hypothetical protein	-
PXV45_RS13300 (2620178)	2620178..2620792	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	2576909..2631367	54458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T273766 WP_001025401.1 NZ_CP119109:c2616809-2616564 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT273766 NZ_CP119109:2616230-2616595 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin