Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 882467..882805 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag PXV45_RS04475 Protein ID WP_011447039.1
Coordinates 882467..882643 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 882631..882805 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS04455 877702..881487 + 3786 WP_000582186.1 phage tail spike protein -
PXV45_RS04460 881477..881629 + 153 WP_001153681.1 hypothetical protein -
PXV45_RS04465 881676..881963 + 288 WP_001040261.1 hypothetical protein -
PXV45_RS04470 882021..882317 + 297 WP_000539688.1 DUF2951 domain-containing protein -
PXV45_RS04475 882467..882643 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 882631..882805 - 175 - - Antitoxin
PXV45_RS04485 882855..883109 + 255 WP_000611512.1 phage holin -
PXV45_RS04490 883121..883876 + 756 WP_000861038.1 CHAP domain-containing protein -
PXV45_RS04495 884067..884558 + 492 WP_000920041.1 staphylokinase -
PXV45_RS04500 885169..885519 + 351 WP_000702263.1 complement inhibitor SCIN-A -
PXV45_RS04505 885572..885832 - 261 WP_001791826.1 hypothetical protein -
PXV45_RS04510 886143..886322 - 180 WP_000669789.1 hypothetical protein -
PXV45_RS04515 886694..886891 - 198 WP_000239614.1 phospholipase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / scn 834078..885519 51441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T273760 WP_011447039.1 NZ_CP119109:882467-882643 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT273760 NZ_CP119109:c882805-882631 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References