Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2049567..2050157 Replicon chromosome
Accession NZ_CP119108
Organism Microbacterium sp. KACC 23027

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag PU630_RS09880 Protein ID WP_275276907.1
Coordinates 2049876..2050157 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PU630_RS09875 Protein ID WP_275276906.1
Coordinates 2049567..2049866 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU630_RS09850 (PU630_09850) 2046158..2046604 + 447 WP_275276901.1 VOC family protein -
PU630_RS09855 (PU630_09855) 2046667..2047353 - 687 WP_275276902.1 hypothetical protein -
PU630_RS09860 (PU630_09860) 2047505..2048266 - 762 WP_275276903.1 glucose 1-dehydrogenase -
PU630_RS09865 (PU630_09865) 2048486..2048779 - 294 WP_275276904.1 hypothetical protein -
PU630_RS09870 (PU630_09870) 2049113..2049451 + 339 WP_275276905.1 hypothetical protein -
PU630_RS09875 (PU630_09875) 2049567..2049866 - 300 WP_275276906.1 HigA family addiction module antitoxin Antitoxin
PU630_RS09880 (PU630_09880) 2049876..2050157 - 282 WP_275276907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PU630_RS09885 (PU630_09885) 2050198..2050521 - 324 WP_275276908.1 hypothetical protein -
PU630_RS09890 (PU630_09890) 2050609..2051682 - 1074 WP_275276909.1 redox-regulated ATPase YchF -
PU630_RS09895 (PU630_09895) 2051719..2052423 - 705 WP_275276910.1 HAD family hydrolase -
PU630_RS09900 (PU630_09900) 2052420..2053169 - 750 WP_275276911.1 class I SAM-dependent methyltransferase -
PU630_RS09905 (PU630_09905) 2053229..2053831 + 603 WP_275276912.1 exonuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10871.27 Da        Isoelectric Point: 8.1098

>T273748 WP_275276907.1 NZ_CP119108:c2050157-2049876 [Microbacterium sp. KACC 23027]
VIRSFGDRDTELVWLREYAKHIDSRIHKAANRKLHLLDAAGTLEALRVPPGNRLEALKGDRRGQHSIRINDQWRICFRWT
EAGPEDVTIEDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10908.54 Da        Isoelectric Point: 6.4598

>AT273748 WP_275276906.1 NZ_CP119108:c2049866-2049567 [Microbacterium sp. KACC 23027]
MSEKLYPPIHPGEILMEDFINGFGITQNKVAVAIGVPPRRINEIVHGKRAITADTALRLGQYFGVDPQFWLNLQSQYELE
LARDAGAASYAGITPLRVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References