Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1847083..1847753 Replicon chromosome
Accession NZ_CP119108
Organism Microbacterium sp. KACC 23027

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PU630_RS08875 Protein ID WP_275276723.1
Coordinates 1847394..1847753 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag PU630_RS08870 Protein ID WP_275280061.1
Coordinates 1847083..1847313 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU630_RS08850 (PU630_08850) 1844551..1844817 + 267 WP_275276719.1 hypothetical protein -
PU630_RS08855 (PU630_08855) 1844855..1845967 + 1113 WP_275276720.1 GNAT family N-acetyltransferase -
PU630_RS08860 (PU630_08860) 1845957..1846634 - 678 WP_275276721.1 HAD family hydrolase -
PU630_RS08865 (PU630_08865) 1846650..1847051 - 402 WP_275276722.1 hypothetical protein -
PU630_RS08870 (PU630_08870) 1847083..1847313 - 231 WP_275280061.1 helix-turn-helix transcriptional regulator Antitoxin
PU630_RS08875 (PU630_08875) 1847394..1847753 - 360 WP_275276723.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PU630_RS08880 (PU630_08880) 1848564..1849460 - 897 WP_275276724.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
PU630_RS08885 (PU630_08885) 1849462..1850151 - 690 WP_275276725.1 ribonuclease III -
PU630_RS08890 (PU630_08890) 1850162..1850371 - 210 WP_275276726.1 50S ribosomal protein L32 -
PU630_RS08895 (PU630_08895) 1850392..1850949 - 558 WP_275276727.1 YceD family protein -
PU630_RS08900 (PU630_08900) 1850966..1851463 - 498 WP_275276728.1 pantetheine-phosphate adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-62)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13614.41 Da        Isoelectric Point: 5.2427

>T273747 WP_275276723.1 NZ_CP119108:c1847753-1847394 [Microbacterium sp. KACC 23027]
VWEVDLELIEEWLLSLDDASYDQVVAAVELLEEHGPHLGRPLVDAVRASRHKNMKELRPGSSGRSELRVLFAFDPDRQAI
LLVAGDKAGNWKNWYKKNIPVADDLFDVHLRDQKRTKGE

Download         Length: 360 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8472.63 Da        Isoelectric Point: 5.1369

>AT273747 WP_275280061.1 NZ_CP119108:c1847313-1847083 [Microbacterium sp. KACC 23027]
MLGEVRAYRLRELREALGLTQEELAERIGVGQRQVSKIENGDLDSARVGTIRKYLEAVGGDLVVEYVSGDRRLQVA

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References