Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743688..744463 Replicon chromosome
Accession NZ_CP119013
Organism Klebsiella pneumoniae strain CR-hvKP005

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag PY729_RS03720 Protein ID WP_004150910.1
Coordinates 743978..744463 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PY729_RS03715 Protein ID WP_004150912.1
Coordinates 743688..743981 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY729_RS03695 (PY729_03695) 738896..739498 - 603 WP_062954968.1 short chain dehydrogenase -
PY729_RS03700 (PY729_03700) 739596..740507 + 912 WP_004188550.1 LysR family transcriptional regulator -
PY729_RS03705 (PY729_03705) 740508..741656 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
PY729_RS03710 (PY729_03710) 741667..743043 - 1377 WP_004217775.1 cystathionine beta-synthase -
PY729_RS03715 (PY729_03715) 743688..743981 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PY729_RS03720 (PY729_03720) 743978..744463 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
PY729_RS03725 (PY729_03725) 745167..745760 + 594 WP_004188553.1 hypothetical protein -
PY729_RS03730 (PY729_03730) 745857..746073 + 217 Protein_733 transposase -
PY729_RS03735 (PY729_03735) 746679..747551 + 873 WP_004188557.1 ParA family protein -
PY729_RS03740 (PY729_03740) 747551..747934 + 384 WP_004150906.1 hypothetical protein -
PY729_RS03745 (PY729_03745) 747927..749294 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 745857..746009 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T273708 WP_004150910.1 NZ_CP119013:743978-744463 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT273708 WP_004150912.1 NZ_CP119013:743688-743981 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References