Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 52966..53618 Replicon plasmid pK520-TEM
Accession NZ_CP118992
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name higB Uniprot ID A0A6I4WW70
Locus tag PYU98_RS25810 Protein ID WP_024943279.1
Coordinates 52966..53316 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYU98_RS25815 Protein ID WP_024943280.1
Coordinates 53316..53618 (+) Length 101 a.a.

Genomic Context

PYU98_RS25780PYU98_RS25790PYU98_RS25795PYU98_RS25800PYU98_RS25805PYU98_RS25810PYU98_RS25815PYU98_RS25825PYU98_RS25775PYU98_RS25785PYU98_RS25820PYU98_RS25830PYU98_RS25835
Location: 49330..49977 (648 bp)
Type: Others
Protein ID: WP_270808117.1
Location: 50504..51205 (702 bp)
Type: Others
Protein ID: WP_182928087.1
Location: 51372..51569 (198 bp)
Type: Others
Protein ID: WP_275058444.1
Location: 51604..52521 (918 bp)
Type: Others
Protein ID: WP_270808123.1
Location: 52662..52907 (246 bp)
Type: Others
Protein ID: WP_024943278.1
Location: 52966..53316 (351 bp)
Type: Toxin
Protein ID: WP_024943279.1
Location: 53316..53618 (303 bp)
Type: Antitoxin
Protein ID: WP_024943280.1
Location: 54172..54849 (678 bp)
Type: Others
Protein ID: WP_275058445.1
Location: 48381..49331 (951 bp)
Type: Others
Protein ID: Protein_51
Location: 49971..50327 (357 bp)
Type: Others
Protein ID: WP_270808119.1
Location: 53711..54115 (405 bp)
Type: Others
Protein ID: WP_270808127.1
Location: 54872..57904 (3033 bp)
Type: Others
Protein ID: WP_039272567.1
Location: 57901..58494 (594 bp)
Type: Others
Protein ID: WP_039272634.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PYU98_RS25775 (PYU98_25775)48381..49331-951Protein_51IS4 family transposase-
PYU98_RS25780 (PYU98_25780)49330..49977+648WP_270808117.1IS5 family transposase-
PYU98_RS25785 (PYU98_25785)49971..50327-357WP_270808119.1hypothetical protein-
PYU98_RS25790 (PYU98_25790)50504..51205+702WP_182928087.1gamma-glutamyl-gamma-aminobutyrate hydrolase family protein-
PYU98_RS25795 (PYU98_25795)51372..51569+198WP_275058444.1hypothetical protein-
PYU98_RS25800 (PYU98_25800)51604..52521+918WP_270808123.1IS5 family transposase-
PYU98_RS25805 (PYU98_25805)52662..52907+246WP_024943278.1hypothetical protein-
PYU98_RS25810 (PYU98_25810)52966..53316+351WP_024943279.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PYU98_RS25815 (PYU98_25815)53316..53618+303WP_024943280.1helix-turn-helix transcriptional regulatorAntitoxin
PYU98_RS25820 (PYU98_25820)53711..54115-405WP_270808127.1IS200/IS605 family transposase-
PYU98_RS25825 (PYU98_25825)54172..54849+678WP_275058445.1transposase-
PYU98_RS25830 (PYU98_25830)54872..57904-3033WP_039272567.1Tn3 family transposase-
PYU98_RS25835 (PYU98_25835)57901..58494-594WP_039272634.1recombinase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaTEM-1C-1..7388173881
-insideIScluster/TnblaTEM-1C-33161..7135838197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12937.79 Da        Isoelectric Point: 5.7350

>T273703 WP_024943279.1 NZ_CP118992:52966-53316 [Aeromonas allosaccharophila]
MWTVKTTSLFDVWFDEQDEATQEKVLAGLLALAQGGPSVGRPLVDTIKGSRFTNLKELRVQHQGDPLRAFFAFDPLRQAI
VLCAGNKGGNDKRFYKEMLPVAEAEYAKHLTELEVG

Download         Length: 351 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11137.84 Da        Isoelectric Point: 5.1667

>AT273703 WP_024943280.1 NZ_CP118992:53316-53618 [Aeromonas allosaccharophila]
MGRTLNEMLASRSVDSQQRIQEMANELLLEVRLQALREELEVSQVELASALGISQPAVVAMEQRGNDIKLSTMKRYVEAM
GGKLRVDVELPTGRHVGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I4WW70

Antitoxin

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Source
ID
Structure
No matching records found

References