Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 204432..205083 Replicon plasmid unnamed1
Accession NZ_CP118964
Organism Acinetobacter lwoffii strain DSM 2403

Toxin (Protein)


Gene name higB Uniprot ID N9FYW4
Locus tag PYW33_RS16330 Protein ID WP_000269911.1
Coordinates 204432..204788 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYW33_RS16335 Protein ID WP_001140620.1
Coordinates 204781..205083 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW33_RS16305 201217..201555 + 339 WP_004897649.1 hypothetical protein -
PYW33_RS16310 201542..202486 + 945 WP_004668309.1 copper resistance protein B -
PYW33_RS16315 202666..202911 + 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
PYW33_RS16320 202901..203194 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin -
PYW33_RS16325 203324..203653 - 330 WP_004733205.1 four-helix bundle copper-binding protein -
PYW33_RS16330 204432..204788 + 357 WP_000269911.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYW33_RS16335 204781..205083 + 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
PYW33_RS16340 205125..205286 - 162 Protein_226 IS6 family transposase -
PYW33_RS16345 205339..205773 + 435 Protein_227 recombinase family protein -
PYW33_RS16350 205784..206773 + 990 WP_130908661.1 arsenic resistance protein -
PYW33_RS16355 206862..208691 - 1830 WP_130908662.1 ferrous iron transporter B -
PYW33_RS16360 208681..208941 - 261 WP_004665962.1 FeoA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..221373 221373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13600.60 Da        Isoelectric Point: 7.1651

>T273673 WP_000269911.1 NZ_CP118964:204432-204788 [Acinetobacter lwoffii]
MWTVITTDLFNQWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT273673 WP_001140620.1 NZ_CP118964:204781-205083 [Acinetobacter lwoffii]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RIA3

Antitoxin

Source ID Structure

References