Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1616..2267 Replicon plasmid unnamed1
Accession NZ_CP118964
Organism Acinetobacter lwoffii strain DSM 2403

Toxin (Protein)


Gene name higB Uniprot ID N9NM16
Locus tag PYW33_RS15215 Protein ID WP_004668307.1
Coordinates 1616..1972 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYW33_RS15220 Protein ID WP_001140620.1
Coordinates 1965..2267 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW33_RS15210 1..978 - 978 WP_004761028.1 TerC family protein -
PYW33_RS15215 1616..1972 + 357 WP_004668307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYW33_RS15220 1965..2267 + 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
PYW33_RS15225 2309..2470 - 162 Protein_3 IS6 family transposase -
PYW33_RS15230 2564..2956 - 393 WP_000550240.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
PYW33_RS15235 3046..4326 + 1281 WP_004897603.1 cation transporter -
PYW33_RS15240 4453..4923 - 471 Protein_6 IS3 family transposase -
PYW33_RS15245 5003..6244 - 1242 WP_004644827.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..221373 221373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13610.64 Da        Isoelectric Point: 7.1651

>T273669 WP_004668307.1 NZ_CP118964:1616-1972 [Acinetobacter lwoffii]
MWTVITTDLFNQWLEQQDEPTQEKVLAALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT273669 WP_001140620.1 NZ_CP118964:1965-2267 [Acinetobacter lwoffii]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9NM16

Antitoxin

Source ID Structure

References