Detailed information of TA system TA273663

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2777102..2777543
• Replicon: chromosome
• Accession: NZ_CP118962
• Organism: Enterococcus faecalis strain DSM 20478

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: PYW42_RS13705
• Protein ID: WP_002381035.1
• Coordinates: 2777400..2777543 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2777102..2777303 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYW42_RS13680	2772236..2773228	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
PYW42_RS13685	2773492..2774130	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
PYW42_RS13690	2774816..2776432	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
PYW42_RS13695	2776761..2776910	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
PYW42_RS13700	2777029..2777169	+	141	WP_073340360.1	putative holin-like toxin	-
-	2777102..2777303	-	202	-	-	Antitoxin
PYW42_RS13705	2777400..2777543	+	144	WP_002381035.1	putative holin-like toxin	Toxin
PYW42_RS13710	2777738..2781565	-	3828	WP_010816211.1	WxL domain-containing protein	-
PYW42_RS13715	2781552..2781914	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T273663 WP_002381035.1 NZ_CP118962:2777400-2777543 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 202 bp

>AT273663 NZ_CP118962:c2777303-2777102 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin