Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2777102..2777543 Replicon chromosome
Accession NZ_CP118962
Organism Enterococcus faecalis strain DSM 20478

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag PYW42_RS13705 Protein ID WP_002381035.1
Coordinates 2777400..2777543 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2777102..2777303 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW42_RS13680 2772236..2773228 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
PYW42_RS13685 2773492..2774130 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
PYW42_RS13690 2774816..2776432 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -
PYW42_RS13695 2776761..2776910 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
PYW42_RS13700 2777029..2777169 + 141 WP_073340360.1 putative holin-like toxin -
- 2777102..2777303 - 202 - - Antitoxin
PYW42_RS13705 2777400..2777543 + 144 WP_002381035.1 putative holin-like toxin Toxin
PYW42_RS13710 2777738..2781565 - 3828 WP_010816211.1 WxL domain-containing protein -
PYW42_RS13715 2781552..2781914 - 363 WP_002378868.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T273663 WP_002381035.1 NZ_CP118962:2777400-2777543 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 202 bp

>AT273663 NZ_CP118962:c2777303-2777102 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References