Detailed information of TA system TA273654

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2703884..2704146
• Replicon: chromosome
• Accession: NZ_CP118962
• Organism: Enterococcus faecalis strain DSM 20478

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PYW42_RS13365
• Protein ID: WP_002367458.1
• Coordinates: 2704003..2704146 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2703884..2704070 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYW42_RS13350	2699341..2702085	+	2745	WP_025189146.1	glycosyl hydrolase family 65 protein	-
PYW42_RS13355	2702100..2702750	+	651	WP_002389419.1	beta-phosphoglucomutase	-
PYW42_RS13360	2703170..2703763	+	594	WP_002389391.1	PBECR4 domain-containing protein	-
-	2703884..2704070	+	187	-	-	Antitoxin
PYW42_RS13365	2704003..2704146	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
PYW42_RS13370	2704378..2705349	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
PYW42_RS13375	2705524..2705961	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
PYW42_RS13380	2706094..2706648	-	555	WP_002354869.1	Maf family protein	-
PYW42_RS13385	2706673..2708805	-	2133	WP_002389406.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T273654 WP_002367458.1 NZ_CP118962:c2704146-2704003 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT273654 NZ_CP118962:2703884-2704070 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin