Detailed information of TA system TA273651

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2632775..2633034
• Replicon: chromosome
• Accession: NZ_CP118962
• Organism: Enterococcus faecalis strain DSM 20478

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PYW42_RS13035
• Protein ID: WP_075551663.1
• Coordinates: 2632933..2633034 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2632775..2632984 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYW42_RS13005	2628028..2628981	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
PYW42_RS13010	2629020..2629775	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PYW42_RS13015	2629772..2630737	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PYW42_RS13020	2630734..2631681	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PYW42_RS13025	2631866..2632318	+	453	WP_002389410.1	YueI family protein	-
PYW42_RS13030	2632500..2632601	-	102	WP_021164441.1	putative holin-like toxin	-
-	2632775..2632984	+	210	-	-	Antitoxin
PYW42_RS13035	2632933..2633034	-	102	WP_075551663.1	putative holin-like toxin	Toxin
PYW42_RS13040	2633224..2635494	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PYW42_RS13045	2635665..2636165	+	501	WP_002372831.1	cysteine hydrolase family protein	-
PYW42_RS13050	2636564..2637460	+	897	WP_002389477.1	YitT family protein	-
PYW42_RS13055	2637511..2637909	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T273651 WP_075551663.1 NZ_CP118962:c2633034-2632933 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT273651 NZ_CP118962:2632775-2632984 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin