Detailed information of TA system TA273646

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2632344..2632601
• Replicon: chromosome
• Accession: NZ_CP118962
• Organism: Enterococcus faecalis strain DSM 20478

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PYW42_RS13030
• Protein ID: WP_021164441.1
• Coordinates: 2632500..2632601 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2632344..2632551 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYW42_RS13005	2628028..2628981	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
PYW42_RS13010	2629020..2629775	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PYW42_RS13015	2629772..2630737	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
PYW42_RS13020	2630734..2631681	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PYW42_RS13025	2631866..2632318	+	453	WP_002389410.1	YueI family protein	-
-	2632344..2632551	+	208	-	-	Antitoxin
PYW42_RS13030	2632500..2632601	-	102	WP_021164441.1	putative holin-like toxin	Toxin
PYW42_RS13035	2632933..2633034	-	102	WP_075551663.1	putative holin-like toxin	-
PYW42_RS13040	2633224..2635494	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PYW42_RS13045	2635665..2636165	+	501	WP_002372831.1	cysteine hydrolase family protein	-
PYW42_RS13050	2636564..2637460	+	897	WP_002389477.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T273646 WP_021164441.1 NZ_CP118962:c2632601-2632500 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT273646 NZ_CP118962:2632344-2632551 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin