Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355163..355809 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag PX704_RS01640 Protein ID WP_016529833.1
Coordinates 355163..355510 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag PX704_RS01645 Protein ID WP_004188315.1
Coordinates 355510..355809 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS01630 (351089) 351089..352522 + 1434 WP_002920564.1 glycogen synthase GlgA -
PX704_RS01635 (352540) 352540..354987 + 2448 WP_002920561.1 glycogen phosphorylase -
PX704_RS01640 (355163) 355163..355510 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PX704_RS01645 (355510) 355510..355809 + 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
PX704_RS01650 (355872) 355872..357380 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
PX704_RS01655 (357585) 357585..357914 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
PX704_RS01660 (357965) 357965..358795 + 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
PX704_RS01665 (358845) 358845..359603 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T273606 WP_016529833.1 NZ_CP118936:355163-355510 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT273606 WP_004188315.1 NZ_CP118936:355510-355809 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References