Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 328978..329564 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag PX704_RS01530 Protein ID WP_002920800.1
Coordinates 329196..329564 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag PX704_RS01525 Protein ID WP_004174006.1
Coordinates 328978..329199 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS01505 (325135) 325135..326061 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PX704_RS01510 (326058) 326058..327335 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
PX704_RS01515 (327332) 327332..328099 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PX704_RS01520 (328101) 328101..328814 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
PX704_RS01525 (328978) 328978..329199 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PX704_RS01530 (329196) 329196..329564 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PX704_RS01535 (329837) 329837..331153 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
PX704_RS01540 (331260) 331260..332147 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
PX704_RS01545 (332144) 332144..332989 + 846 WP_239619486.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
PX704_RS01550 (332991) 332991..334061 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 326058..334798 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T273605 WP_002920800.1 NZ_CP118936:329196-329564 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT273605 WP_004174006.1 NZ_CP118936:328978-329199 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References