Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4083583..4084235 Replicon chromosome
Accession NZ_CP118932
Organism Serratia marcescens strain RX11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PXW05_RS19545 Protein ID WP_004931830.1
Coordinates 4083583..4083927 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag PXW05_RS19550 Protein ID WP_004931828.1
Coordinates 4083933..4084235 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXW05_RS19535 (PXW05_19535) 4079925..4082183 - 2259 WP_275095132.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
PXW05_RS19540 (PXW05_19540) 4082404..4083423 + 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
PXW05_RS19545 (PXW05_19545) 4083583..4083927 + 345 WP_004931830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXW05_RS19550 (PXW05_19550) 4083933..4084235 + 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
PXW05_RS19555 (PXW05_19555) 4084263..4085525 - 1263 WP_265261390.1 diaminopimelate decarboxylase -
PXW05_RS19560 (PXW05_19560) 4085659..4086582 + 924 WP_275095133.1 LysR family transcriptional regulator -
PXW05_RS19565 (PXW05_19565) 4086610..4087518 - 909 WP_015378928.1 LysR family transcriptional regulator -
PXW05_RS19570 (PXW05_19570) 4087627..4088511 + 885 WP_004931820.1 MBL fold metallo-hydrolase -
PXW05_RS19575 (PXW05_19575) 4088586..4089233 + 648 WP_004931818.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13383.44 Da        Isoelectric Point: 10.6087

>T273600 WP_004931830.1 NZ_CP118932:4083583-4083927 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT273600 WP_004931828.1 NZ_CP118932:4083933-4084235 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References