Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3351499..3352159 Replicon chromosome
Accession NZ_CP118932
Organism Serratia marcescens strain RX11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PXW05_RS16130 Protein ID WP_015378478.1
Coordinates 3351806..3352159 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6G8TPX9
Locus tag PXW05_RS16125 Protein ID WP_004935502.1
Coordinates 3351499..3351801 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXW05_RS16100 (PXW05_16100) 3347052..3347780 - 729 WP_261803215.1 SDR family oxidoreductase -
PXW05_RS16105 (PXW05_16105) 3347823..3348458 - 636 WP_015378474.1 SDR family oxidoreductase -
PXW05_RS16110 (PXW05_16110) 3348474..3349409 - 936 WP_275094975.1 alpha/beta hydrolase -
PXW05_RS16115 (PXW05_16115) 3349409..3350329 - 921 WP_275094976.1 alpha/beta hydrolase -
PXW05_RS16120 (PXW05_16120) 3350468..3351376 + 909 WP_004935498.1 LysR family transcriptional regulator -
PXW05_RS16125 (PXW05_16125) 3351499..3351801 - 303 WP_004935502.1 XRE family transcriptional regulator Antitoxin
PXW05_RS16130 (PXW05_16130) 3351806..3352159 - 354 WP_015378478.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXW05_RS16135 (PXW05_16135) 3352598..3353893 + 1296 WP_004935508.1 MFS transporter -
PXW05_RS16140 (PXW05_16140) 3353920..3354726 + 807 WP_275094977.1 substrate-binding domain-containing protein -
PXW05_RS16145 (PXW05_16145) 3354701..3355600 - 900 WP_275094978.1 LysR family transcriptional regulator -
PXW05_RS16150 (PXW05_16150) 3355693..3356058 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3345483..3372665 27182


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13595.58 Da        Isoelectric Point: 9.0493

>T273598 WP_015378478.1 NZ_CP118932:c3352159-3351806 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11142.96 Da        Isoelectric Point: 5.1992

>AT273598 WP_004935502.1 NZ_CP118932:c3351801-3351499 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G8TPX9

References