Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731730..732505 Replicon chromosome
Accession NZ_CP118906
Organism Klebsiella pneumoniae strain T-hvKP

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag PXG78_RS03620 Protein ID WP_004889762.1
Coordinates 732020..732505 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PXG78_RS03615 Protein ID WP_004150912.1
Coordinates 731730..732023 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG78_RS03595 (726939) 726939..727541 - 603 WP_002916735.1 short chain dehydrogenase -
PXG78_RS03600 (727639) 727639..728550 + 912 WP_014906929.1 LysR family transcriptional regulator -
PXG78_RS03605 (728551) 728551..729699 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
PXG78_RS03610 (729710) 729710..731086 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
PXG78_RS03615 (731730) 731730..732023 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PXG78_RS03620 (732020) 732020..732505 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
PXG78_RS03625 (733209) 733209..733802 + 594 WP_004188553.1 hypothetical protein -
PXG78_RS03630 (733899) 733899..734115 + 217 Protein_714 transposase -
PXG78_RS03640 (734793) 734793..735506 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 733899..734051 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T273549 WP_004889762.1 NZ_CP118906:732020-732505 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT273549 WP_004150912.1 NZ_CP118906:731730-732023 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References