Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736795..737570 Replicon chromosome
Accession NZ_CP118901
Organism Klebsiella pneumoniae strain CRKP

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag PXG74_RS03685 Protein ID WP_021314147.1
Coordinates 737085..737570 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PXG74_RS03680 Protein ID WP_004150912.1
Coordinates 736795..737088 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG74_RS03660 (732003) 732003..732605 - 603 WP_002916735.1 short chain dehydrogenase -
PXG74_RS03665 (732703) 732703..733614 + 912 WP_004188550.1 LysR family transcriptional regulator -
PXG74_RS03670 (733615) 733615..734763 - 1149 WP_032417597.1 PLP-dependent aspartate aminotransferase family protein -
PXG74_RS03675 (734774) 734774..736150 - 1377 WP_073553579.1 cystathionine beta-synthase -
PXG74_RS03680 (736795) 736795..737088 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PXG74_RS03685 (737085) 737085..737570 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
PXG74_RS03690 (738274) 738274..738867 + 594 WP_004188553.1 hypothetical protein -
PXG74_RS03695 (738964) 738964..739180 + 217 Protein_726 transposase -
PXG74_RS03705 (739695) 739695..740408 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 738964..739116 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T273532 WP_021314147.1 NZ_CP118901:737085-737570 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT273532 WP_004150912.1 NZ_CP118901:736795-737088 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References