Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 8020..8605 Replicon plasmid unnamed3
Accession NZ_CP118895
Organism Acinetobacter sp. TAC-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PYV58_RS22815 Protein ID WP_180042155.1
Coordinates 8020..8340 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYV58_RS22820 Protein ID WP_180042153.1
Coordinates 8333..8605 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYV58_RS22780 (PYV58_22780) 3600..4136 - 537 WP_265755884.1 porin family protein -
PYV58_RS22785 (PYV58_22785) 4537..4824 + 288 WP_275059842.1 BrnT family toxin -
PYV58_RS22790 (PYV58_22790) 4811..5125 + 315 WP_275059843.1 BrnA antitoxin family protein -
PYV58_RS22795 (PYV58_22795) 5388..5804 - 417 Protein_8 hypothetical protein -
PYV58_RS22800 (PYV58_22800) 6002..6799 - 798 WP_086374408.1 protein phosphatase 2C domain-containing protein -
PYV58_RS22805 (PYV58_22805) 6861..7223 - 363 WP_275059837.1 hypothetical protein -
PYV58_RS22810 (PYV58_22810) 7289..7822 - 534 WP_180042157.1 hypothetical protein -
PYV58_RS22815 (PYV58_22815) 8020..8340 + 321 WP_180042155.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYV58_RS22820 (PYV58_22820) 8333..8605 + 273 WP_180042153.1 NadS family protein Antitoxin
PYV58_RS22825 (PYV58_22825) 9151..9540 + 390 Protein_14 hypothetical protein -
PYV58_RS22830 (PYV58_22830) 9592..9885 + 294 WP_227505690.1 hypothetical protein -
PYV58_RS22835 (PYV58_22835) 9879..10343 + 465 WP_025464221.1 hypothetical protein -
PYV58_RS22840 (PYV58_22840) 10547..11110 - 564 WP_275059838.1 plasmid replication DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11749 11749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(35-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12181.05 Da        Isoelectric Point: 8.8679

>T273529 WP_180042155.1 NZ_CP118895:8020-8340 [Acinetobacter sp. TAC-1]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLLQPDKGDVVKNGGGIRKVRCAQGNKGKSGGIRVIYYWVNEDHQIFFLLAY
PKSVKDTLTDKETAILRQLVKEQLHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10169.55 Da        Isoelectric Point: 5.7134

>AT273529 WP_180042153.1 NZ_CP118895:8333-8605 [Acinetobacter sp. TAC-1]
MDNNLFDDLVSSIEEAGAIKRKEIQASRITELELPDIKEVREKTGLSQVEFASRLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References