Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3112..3697 Replicon plasmid unnamed2
Accession NZ_CP118894
Organism Acinetobacter sp. TAC-1

Toxin (Protein)


Gene name higB Uniprot ID V2VZQ9
Locus tag PYV58_RS22685 Protein ID WP_000897308.1
Coordinates 3377..3697 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PYV58_RS22680 Protein ID WP_000369783.1
Coordinates 3112..3384 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYV58_RS22665 (PYV58_22665) 1045..1290 - 246 Protein_1 transcriptional repressor -
PYV58_RS22670 (PYV58_22670) 1274..1861 - 588 WP_051568202.1 hypothetical protein -
PYV58_RS22675 (PYV58_22675) 1970..2536 - 567 WP_042783562.1 hypothetical protein -
PYV58_RS22680 (PYV58_22680) 3112..3384 - 273 WP_000369783.1 NadS family protein Antitoxin
PYV58_RS22685 (PYV58_22685) 3377..3697 - 321 WP_000897308.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYV58_RS22690 (PYV58_22690) 3850..4506 - 657 WP_018680109.1 hypothetical protein -
PYV58_RS22695 (PYV58_22695) 4506..5666 - 1161 WP_018680110.1 ATP-binding protein -
PYV58_RS22700 (PYV58_22700) 5829..6050 - 222 WP_042783569.1 hypothetical protein -
PYV58_RS22705 (PYV58_22705) 6047..6403 - 357 WP_042783570.1 hypothetical protein -
PYV58_RS22710 (PYV58_22710) 6443..7333 - 891 WP_042783571.1 MobA/MobL family protein -
PYV58_RS22715 (PYV58_22715) 7545..8267 + 723 WP_042783572.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14301 14301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(38-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12193.07 Da        Isoelectric Point: 6.9809

>T273527 WP_000897308.1 NZ_CP118894:c3697-3377 [Acinetobacter sp. TAC-1]
MLFIETSIFTKQIKELVSDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILRQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10094.49 Da        Isoelectric Point: 7.2040

>AT273527 WP_000369783.1 NZ_CP118894:c3384-3112 [Acinetobacter sp. TAC-1]
MDNNLFDDLVASIKEAGAIKRNEVQASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V2VZQ9

Antitoxin

Source ID Structure

References