Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 81665..82389 Replicon plasmid p12100-PER
Accession NZ_CP118865
Organism Providencia rettgeri strain 12100

Toxin (Protein)


Gene name higB Uniprot ID A0A8I2DDP5
Locus tag NTP66_RS20810 Protein ID WP_042847414.1
Coordinates 82078..82389 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NTP66_RS20805 Protein ID WP_042847042.1
Coordinates 81665..82081 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP66_RS20780 77144..77362 + 219 WP_042847047.1 hypothetical protein -
NTP66_RS20785 77486..78478 + 993 WP_282563608.1 hypothetical protein -
NTP66_RS20790 78542..79342 + 801 WP_042847045.1 methyltransferase -
NTP66_RS20795 79419..80776 + 1358 WP_227528812.1 IS3 family transposase -
NTP66_RS20800 80919..81587 + 669 WP_283558198.1 hypothetical protein -
NTP66_RS20805 81665..82081 - 417 WP_042847042.1 helix-turn-helix domain-containing protein Antitoxin
NTP66_RS20810 82078..82389 - 312 WP_042847414.1 type II toxin-antitoxin system HigB family toxin Toxin
NTP66_RS20815 82559..83194 + 636 WP_282561991.1 hypothetical protein -
NTP66_RS20820 83586..83864 + 279 WP_162762192.1 hypothetical protein -
NTP66_RS20825 84168..85040 + 873 WP_052219406.1 hypothetical protein -
NTP66_RS20830 86107..86538 + 432 WP_144138807.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(3'')-Ia / qacE / sul1 / blaPER-1 / mph(A) / rmtB2 - 1..315510 315510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12448.21 Da        Isoelectric Point: 10.2553

>T273523 WP_042847414.1 NZ_CP118865:c82389-82078 [Providencia rettgeri]
MHVISREPFDQASKRFPNSAQALSDIYRTLKRDSYQTPDELKKVFPSLDRMKYREKWWVIDISGNSLRMMFFADFDRGKI
FVKHITTHAEYDRLTDHYRRTKA

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15491.49 Da        Isoelectric Point: 4.6438

>AT273523 WP_042847042.1 NZ_CP118865:c82081-81665 [Providencia rettgeri]
MMFQDAVNAAQNLISIVPLLGNSHSREDYEKAVQLVEHLVENDPDNPLIDLICAKIDAYEKTAPEFAEFNERLAKSNGGV
AALRTLMDQYHLNTTDFQDELGSRSYVSRILNGERGLTLEHIKKLSARFNIPASIFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References