Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2454751..2455268 Replicon chromosome
Accession NZ_CP118835
Organism Staphylococcus aureus strain 7051

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PYH51_RS12290 Protein ID WP_000113262.1
Coordinates 2454751..2455017 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PYH51_RS12295 Protein ID WP_000584499.1
Coordinates 2455017..2455268 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH51_RS12260 (2450181) 2450181..2450717 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PYH51_RS12265 (2450950) 2450950..2451774 - 825 WP_045177662.1 formate/nitrite transporter family protein -
PYH51_RS12270 (2451991) 2451991..2452173 - 183 WP_000230294.1 hypothetical protein -
PYH51_RS12275 (2452257) 2452257..2452724 - 468 WP_000153346.1 SRPBCC domain-containing protein -
PYH51_RS12280 (2452910) 2452910..2454457 - 1548 WP_117215958.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PYH51_RS12285 (2454645) 2454645..2454716 - 72 WP_223200558.1 hypothetical protein -
PYH51_RS12290 (2454751) 2454751..2455017 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PYH51_RS12295 (2455017) 2455017..2455268 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYH51_RS12300 (2455433) 2455433..2455534 - 102 WP_001791744.1 hypothetical protein -
PYH51_RS12305 (2455541) 2455541..2456140 - 600 WP_000162812.1 DsbA family protein -
PYH51_RS12310 (2456159) 2456159..2456521 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PYH51_RS12315 (2456776) 2456776..2458026 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
PYH51_RS12320 (2458123) 2458123..2458854 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PYH51_RS12325 (2458851) 2458851..2459570 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T273493 WP_000113262.1 NZ_CP118835:c2455017-2454751 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT273493 WP_000584499.1 NZ_CP118835:c2455268-2455017 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References