Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2511295..2511818 Replicon chromosome
Accession NZ_CP118832
Organism Staphylococcus aureus strain 7053

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag PYH65_RS12570 Protein ID WP_045177693.1
Coordinates 2511295..2511561 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag PYH65_RS12575 Protein ID WP_086095185.1
Coordinates 2511561..2511818 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH65_RS12550 (2506601) 2506601..2507788 - 1188 WP_045177690.1 MFS transporter -
PYH65_RS12555 (2508184) 2508184..2508960 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
PYH65_RS12560 (2508953) 2508953..2509615 - 663 WP_045177691.1 ATP-binding cassette domain-containing protein -
PYH65_RS12565 (2509863) 2509863..2510939 - 1077 WP_001076673.1 M42 family metallopeptidase -
PYH65_RS12570 (2511295) 2511295..2511561 - 267 WP_045177693.1 Txe/YoeB family addiction module toxin Toxin
PYH65_RS12575 (2511561) 2511561..2511818 - 258 WP_086095185.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYH65_RS12580 (2512178) 2512178..2512633 + 456 WP_000732090.1 YehR family lipoprotein -
PYH65_RS12585 (2512801) 2512801..2514378 - 1578 WP_282872635.1 FMN-binding glutamate synthase family protein -
PYH65_RS12590 (2514573) 2514573..2515322 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10684.35 Da        Isoelectric Point: 10.1384

>T273480 WP_045177693.1 NZ_CP118832:c2511561-2511295 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T273480 NZ_CP118832:c2511561-2511295 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9704.75 Da        Isoelectric Point: 4.2813

>AT273480 WP_086095185.1 NZ_CP118832:c2511818-2511561 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKGNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT273480 NZ_CP118832:c2511818-2511561 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGGTAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References