Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2051305..2051719 | Replicon | chromosome |
| Accession | NZ_CP118832 | ||
| Organism | Staphylococcus aureus strain 7053 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | PYH65_RS10150 | Protein ID | WP_001826875.1 |
| Coordinates | 2051468..2051719 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | PYH65_RS10145 | Protein ID | WP_000028424.1 |
| Coordinates | 2051305..2051478 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PYH65_RS10085 (2047353) | 2047353..2047820 | - | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
| PYH65_RS10090 (2047949) | 2047949..2048293 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| PYH65_RS10095 (2048309) | 2048309..2048761 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| PYH65_RS10100 (2048876) | 2048876..2049337 | - | 462 | WP_000282756.1 | hypothetical protein | - |
| PYH65_RS10105 (2049360) | 2049360..2049560 | - | 201 | WP_001570807.1 | DUF1514 family protein | - |
| PYH65_RS10110 (2049560) | 2049560..2049685 | - | 126 | WP_031783376.1 | transcriptional regulator | - |
| PYH65_RS10115 (2049678) | 2049678..2049881 | - | 204 | WP_001072793.1 | hypothetical protein | - |
| PYH65_RS10120 (2049882) | 2049882..2050073 | - | 192 | Protein_1955 | hypothetical protein | - |
| PYH65_RS10125 (2050070) | 2050070..2050276 | - | 207 | WP_000195826.1 | DUF1381 domain-containing protein | - |
| PYH65_RS10130 (2050313) | 2050313..2050846 | - | 534 | WP_025920701.1 | dUTP diphosphatase | - |
| PYH65_RS10135 (2050861) | 2050861..2051022 | - | 162 | WP_000889679.1 | hypothetical protein | - |
| PYH65_RS10140 (2051023) | 2051023..2051304 | - | 282 | WP_000454993.1 | hypothetical protein | - |
| PYH65_RS10145 (2051305) | 2051305..2051478 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| PYH65_RS10150 (2051468) | 2051468..2051719 | - | 252 | WP_001826875.1 | DUF1024 family protein | Toxin |
| PYH65_RS10155 (2051734) | 2051734..2051976 | - | 243 | WP_000131389.1 | SAV1978 family virulence-associated passenger protein | - |
| PYH65_RS10160 (2051980) | 2051980..2052348 | - | 369 | WP_016028254.1 | SA1788 family PVL leukocidin-associated protein | - |
| PYH65_RS10165 (2052361) | 2052361..2052765 | - | 405 | WP_000401978.1 | RusA family crossover junction endodeoxyribonuclease | - |
| PYH65_RS10170 (2052774) | 2052774..2052992 | - | 219 | WP_000338527.1 | hypothetical protein | - |
| PYH65_RS10175 (2052999) | 2052999..2053892 | - | 894 | WP_000148335.1 | DnaD domain-containing protein | - |
| PYH65_RS10180 (2053922) | 2053922..2054392 | - | 471 | WP_000934760.1 | single-stranded DNA-binding protein | - |
| PYH65_RS10185 (2054393) | 2054393..2055010 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| PYH65_RS10190 (2055091) | 2055091..2056011 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak / sea / hlb / groEL | 2022919..2076574 | 53655 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|