Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2454755..2455272 Replicon chromosome
Accession NZ_CP118830
Organism Staphylococcus aureus strain 7054

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PYH54_RS12290 Protein ID WP_000113262.1
Coordinates 2454755..2455021 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PYH54_RS12295 Protein ID WP_000584499.1
Coordinates 2455021..2455272 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH54_RS12260 (2450185) 2450185..2450721 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PYH54_RS12265 (2450954) 2450954..2451778 - 825 WP_045177662.1 formate/nitrite transporter family protein -
PYH54_RS12270 (2451995) 2451995..2452177 - 183 WP_000230294.1 hypothetical protein -
PYH54_RS12275 (2452261) 2452261..2452728 - 468 WP_000153346.1 SRPBCC domain-containing protein -
PYH54_RS12280 (2452914) 2452914..2454461 - 1548 WP_117215958.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PYH54_RS12285 (2454649) 2454649..2454720 - 72 WP_223200558.1 hypothetical protein -
PYH54_RS12290 (2454755) 2454755..2455021 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PYH54_RS12295 (2455021) 2455021..2455272 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYH54_RS12300 (2455437) 2455437..2455538 - 102 WP_001791744.1 hypothetical protein -
PYH54_RS12305 (2455545) 2455545..2456144 - 600 WP_000162812.1 DsbA family protein -
PYH54_RS12310 (2456163) 2456163..2456525 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PYH54_RS12315 (2456780) 2456780..2458030 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
PYH54_RS12320 (2458127) 2458127..2458858 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PYH54_RS12325 (2458855) 2458855..2459574 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T273463 WP_000113262.1 NZ_CP118830:c2455021-2454755 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT273463 WP_000584499.1 NZ_CP118830:c2455272-2455021 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References