Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6543086..6543709 Replicon chromosome
Accession NZ_CP118775
Organism Delftia tsuruhatensis strain ULwDis3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PW274_RS30495 Protein ID WP_126311616.1
Coordinates 6543428..6543709 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1I1B5A1
Locus tag PW274_RS30490 Protein ID WP_026062357.1
Coordinates 6543086..6543385 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PW274_RS30465 (PW274_30465) 6538378..6539169 - 792 WP_126311619.1 SDR family oxidoreductase -
PW274_RS30470 (PW274_30470) 6539263..6540198 + 936 WP_126311618.1 LysR family transcriptional regulator -
PW274_RS30475 (PW274_30475) 6540460..6541233 + 774 WP_016448667.1 ferredoxin--NADP reductase -
PW274_RS30480 (PW274_30480) 6541278..6542084 + 807 WP_126311617.1 IclR family transcriptional regulator -
PW274_RS30485 (PW274_30485) 6542220..6542993 + 774 WP_016448669.1 SDR family oxidoreductase -
PW274_RS30490 (PW274_30490) 6543086..6543385 - 300 WP_026062357.1 HigA family addiction module antitoxin Antitoxin
PW274_RS30495 (PW274_30495) 6543428..6543709 - 282 WP_126311616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PW274_RS30500 (PW274_30500) 6543839..6545014 - 1176 WP_016452145.1 ABC transporter substrate-binding protein -
PW274_RS30505 (PW274_30505) 6545070..6545777 - 708 WP_016448672.1 ABC transporter ATP-binding protein -
PW274_RS30510 (PW274_30510) 6545764..6546528 - 765 WP_016452146.1 ABC transporter ATP-binding protein -
PW274_RS30515 (PW274_30515) 6546515..6547489 - 975 WP_016452147.1 branched-chain amino acid ABC transporter permease -
PW274_RS30520 (PW274_30520) 6547490..6548353 - 864 WP_016448674.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11024.64 Da        Isoelectric Point: 10.1059

>T273437 WP_126311616.1 NZ_CP118775:c6543709-6543428 [Delftia tsuruhatensis]
MTIQSFKCPDTEQLFQQRRVRRWSSIEVVALRKLRMLHAAHVLQDLRGPPGNRLEALHGDRKGQHSIRINDQWRVCFVWT
HEGPSQLEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11004.59 Da        Isoelectric Point: 4.5338

>AT273437 WP_026062357.1 NZ_CP118775:c6543385-6543086 [Delftia tsuruhatensis]
MNKPLNLPTPGEILATEFLEPMGLTQYRLAQAIHVPQTRIAAIVKNGRSITADTALRLARFFGTSVEFWMNLQSQYDADI
AREAIGDELESIEPFALQA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1I1B5A1

References