Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 244060..244650 Replicon chromosome
Accession NZ_CP118772
Organism Alcaligenes faecalis strain JF101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PWH35_RS01085 Protein ID WP_250756474.1
Coordinates 244354..244650 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PWH35_RS01080 Protein ID WP_250756473.1
Coordinates 244060..244344 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWH35_RS01065 (PWH35_01065) 239870..241117 + 1248 WP_009460169.1 D-amino acid dehydrogenase -
PWH35_RS01070 (PWH35_01070) 241309..242319 - 1011 WP_250756471.1 acyltransferase family protein -
PWH35_RS01075 (PWH35_01075) 242598..243965 + 1368 WP_250756472.1 DNA recombination protein RmuC -
PWH35_RS01080 (PWH35_01080) 244060..244344 - 285 WP_250756473.1 HigA family addiction module antitoxin Antitoxin
PWH35_RS01085 (PWH35_01085) 244354..244650 - 297 WP_250756474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWH35_RS01090 (PWH35_01090) 244785..247334 - 2550 WP_250756475.1 EAL domain-containing protein -
PWH35_RS01095 (PWH35_01095) 247527..247805 + 279 WP_009460160.1 acylphosphatase -
PWH35_RS01100 (PWH35_01100) 247970..248863 + 894 WP_026483806.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11092.48 Da        Isoelectric Point: 9.3459

>T273420 WP_250756474.1 NZ_CP118772:c244650-244354 [Alcaligenes faecalis]
MIKSFRHKGLQAYFETGSKSGIQAKHAVRLQIQLTALHAATQAEDMNAPGWKLHKLSGKNPKGQSVQDHYTISVSGNWRL
TFYFEGEDAVLVDYQDYH

Download         Length: 297 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10331.82 Da        Isoelectric Point: 9.8929

>AT273420 WP_250756473.1 NZ_CP118772:c244344-244060 [Alcaligenes faecalis]
MRMHNPSHPGPVLREYLGELSVTEAASRLGVTRAALSRILNGSAGISADMALRLRDALGTSAEMWINMQSHYDLWQAEQK
PRPKVLSFHGPAHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References