Detailed information of TA system TA273414

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2762215..2762552
• Replicon: chromosome
• Accession: NZ_CP118755
• Organism: Enterococcus faecalis strain W5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PWA41_RS13380
• Protein ID: WP_016619108.1
• Coordinates: 2762215..2762358 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2762290..2762552 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PWA41_RS13365 (2757931)	2757931..2758563	-	633	WP_002358972.1	RloB family protein	-
PWA41_RS13370 (2758572)	2758572..2759867	-	1296	WP_275016500.1	AAA family ATPase	-
PWA41_RS13375 (2760329)	2760329..2761945	+	1617	WP_153246973.1	phosphatase PAP2/LCP family protein	-
- (2762041)	2762041..2762104	-	64	NuclAT_8	-	-
PWA41_RS13380 (2762215)	2762215..2762358	+	144	WP_016619108.1	putative holin-like toxin	Toxin
- (2762502)	2762502..2762551	+	50	NuclAT_9	-	-
- (2762290)	2762290..2762552	-	263	NuclAT_7	-	Antitoxin
PWA41_RS13385 (2762553)	2762553..2767244	-	4692	WP_153246974.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T273414 WP_016619108.1 NZ_CP118755:2762215-2762358 [Enterococcus faecalis]
MNVSTKTYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT273414 NZ_CP118755:c2762552-2762290 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGATCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin