Detailed information of TA system TA273408

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2611119..2611378
• Replicon: chromosome
• Accession: NZ_CP118755
• Organism: Enterococcus faecalis strain W5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PWA41_RS12700
• Protein ID: WP_075551663.1
• Coordinates: 2611277..2611378 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2611119..2611328 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PWA41_RS12670 (2606369)	2606369..2607322	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
PWA41_RS12675 (2607361)	2607361..2608116	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PWA41_RS12680 (2608113)	2608113..2609078	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
PWA41_RS12685 (2609075)	2609075..2610022	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PWA41_RS12690 (2610207)	2610207..2610659	+	453	WP_002354958.1	YueI family protein	-
- (2610685)	2610685..2610895	+	211	NuclAT_5	-	-
- (2610722)	2610722..2610899	+	178	NuclAT_4	-	-
PWA41_RS12695 (2610844)	2610844..2610945	-	102	WP_075551663.1	putative holin-like toxin	-
- (2611119)	2611119..2611328	+	210	NuclAT_6	-	Antitoxin
- (2611153)	2611153..2611332	+	180	NuclAT_3	-	-
PWA41_RS12700 (2611277)	2611277..2611378	-	102	WP_075551663.1	putative holin-like toxin	Toxin
PWA41_RS12705 (2611568)	2611568..2613838	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PWA41_RS12710 (2614009)	2614009..2614509	+	501	WP_002365352.1	cysteine hydrolase family protein	-
PWA41_RS12715 (2614812)	2614812..2615708	+	897	WP_002365354.1	YitT family protein	-
PWA41_RS12720 (2615759)	2615759..2616157	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T273408 WP_075551663.1 NZ_CP118755:c2611378-2611277 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT273408 NZ_CP118755:2611119-2611328 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin