Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 550377..550609 Replicon chromosome
Accession NZ_CP118755
Organism Enterococcus faecalis strain W5

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PWA41_RS02840 Protein ID WP_002355568.1
Coordinates 550377..550493 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 550404..550609 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA41_RS02830 (545815) 545815..548073 + 2259 WP_002364805.1 DNA helicase PcrA -
PWA41_RS02835 (548199) 548199..550229 + 2031 WP_002358699.1 NAD-dependent DNA ligase LigA -
PWA41_RS02840 (550377) 550377..550493 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (550404) 550404..550609 - 206 NuclAT_2 - Antitoxin
PWA41_RS02845 (550811) 550811..551116 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PWA41_RS02850 (551116) 551116..552585 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PWA41_RS02855 (552585) 552585..554015 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PWA41_RS02860 (554034) 554034..555122 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T273402 WP_002355568.1 NZ_CP118755:550377-550493 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT273402 NZ_CP118755:c550609-550404 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCGTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References