Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4326286..4326914 Replicon chromosome
Accession NZ_CP118723
Organism Serratia marcescens strain AHRB3

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag PWO23_RS20655 Protein ID WP_016930174.1
Coordinates 4326286..4326576 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PWO23_RS20660 Protein ID WP_016930175.1
Coordinates 4326591..4326914 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO23_RS20645 (PWO23_20655) 4322860..4324881 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PWO23_RS20650 (PWO23_20660) 4324916..4326055 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PWO23_RS20655 (PWO23_20665) 4326286..4326576 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWO23_RS20660 (PWO23_20670) 4326591..4326914 + 324 WP_016930175.1 HigA family addiction module antitoxin Antitoxin
PWO23_RS20665 (PWO23_20675) 4326907..4327419 + 513 WP_016930176.1 M48 family metallopeptidase -
PWO23_RS20670 (PWO23_20680) 4327469..4328449 + 981 WP_274985087.1 Gfo/Idh/MocA family oxidoreductase -
PWO23_RS20675 (PWO23_20685) 4328451..4329182 + 732 WP_079450144.1 glutamine amidotransferase -
PWO23_RS20680 (PWO23_20690) 4329435..4330403 + 969 WP_016930179.1 TerC family protein -
PWO23_RS20685 (PWO23_20695) 4330667..4331902 + 1236 WP_028128305.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T273394 WP_016930174.1 NZ_CP118723:4326286-4326576 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT273394 WP_016930175.1 NZ_CP118723:4326591-4326914 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References