Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1166678..1167264 Replicon chromosome
Accession NZ_CP118677
Organism Pseudomonas juntendi strain GDW21C697WI

Toxin (Protein)


Gene name graT Uniprot ID A0A6I2K6L8
Locus tag PWA60_RS05320 Protein ID WP_029885077.1
Coordinates 1166986..1167264 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PWA60_RS05315 Protein ID WP_029885078.1
Coordinates 1166678..1166977 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA60_RS05290 (PWA60_05290) 1162564..1163373 + 810 WP_009686964.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
PWA60_RS05295 (PWA60_05295) 1163445..1163855 - 411 WP_054881203.1 SufE family protein -
PWA60_RS05300 (PWA60_05300) 1163852..1165057 - 1206 WP_029885081.1 cysteine desulfurase -
PWA60_RS05305 (PWA60_05305) 1165139..1166173 - 1035 WP_009686960.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
PWA60_RS05310 (PWA60_05310) 1166205..1166552 - 348 WP_054881204.1 ArsC family reductase -
PWA60_RS05315 (PWA60_05315) 1166678..1166977 - 300 WP_029885078.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
PWA60_RS05320 (PWA60_05320) 1166986..1167264 - 279 WP_029885077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWA60_RS05325 (PWA60_05325) 1167513..1169159 + 1647 WP_029885076.1 Na+/H+ antiporter -
PWA60_RS05330 (PWA60_05330) 1169703..1170899 - 1197 WP_029888073.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10420.72 Da        Isoelectric Point: 7.1344

>T273371 WP_029885077.1 NZ_CP118677:c1167264-1166986 [Pseudomonas juntendi]
MIQSFSCADTEALFVTGKTRRWSDIKSVAERKLAMLDAATELRDLRSPPGNRLEALSGNRAGQHSIRVNDQWRLCFTWTD
NGPANVEIIDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10903.58 Da        Isoelectric Point: 6.4603

>AT273371 WP_029885078.1 NZ_CP118677:c1166977-1166678 [Pseudomonas juntendi]
MLKNGMRPIHPGEVLREDFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQRHGEEIIGAVQRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I2K6L8

Antitoxin

Source ID Structure

References