Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 588270..588924 Replicon plasmid pVWJL.P1
Accession NZ_CP118630
Organism Pantoea dispersa strain VWJL.P1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PWF83_RS22150 Protein ID WP_058781070.1
Coordinates 588270..588641 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NDM6
Locus tag PWF83_RS22155 Protein ID WP_021508926.1
Coordinates 588625..588924 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWF83_RS22130 (PWF83_22140) 583547..584926 + 1380 WP_275029492.1 heavy metal sensor histidine kinase -
PWF83_RS22135 (PWF83_22145) 584956..585609 - 654 WP_058770319.1 oxygen-insensitive NAD(P)H nitroreductase -
PWF83_RS22140 (PWF83_22150) 585714..586715 - 1002 WP_264444146.1 zinc-binding alcohol dehydrogenase family protein -
PWF83_RS22145 (PWF83_22155) 586852..587769 + 918 WP_058759023.1 LysR family transcriptional regulator -
PWF83_RS22150 (PWF83_22160) 588270..588641 + 372 WP_058781070.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWF83_RS22155 (PWF83_22165) 588625..588924 + 300 WP_021508926.1 XRE family transcriptional regulator Antitoxin
PWF83_RS22160 (PWF83_22170) 589002..589469 - 468 WP_058759022.1 hypothetical protein -
PWF83_RS22165 (PWF83_22175) 589655..590584 - 930 WP_059009262.1 ABC transporter substrate-binding protein -
PWF83_RS22170 (PWF83_22180) 590594..591328 - 735 WP_058776076.1 ABC transporter permease -
PWF83_RS22175 (PWF83_22185) 591312..592028 - 717 WP_058781068.1 ABC transporter ATP-binding protein -
PWF83_RS22180 (PWF83_22190) 592025..592993 - 969 WP_058781067.1 HesA/MoeB/ThiF family protein -
PWF83_RS22185 (PWF83_22195) 593004..593762 - 759 WP_275029503.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..708540 708540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-88)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14338.48 Da        Isoelectric Point: 10.0492

>T273328 WP_058781070.1 NZ_CP118630:588270-588641 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLHIAETEYHHHLNAIGETHNENLG

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11265.00 Da        Isoelectric Point: 6.7255

>AT273328 WP_021508926.1 NZ_CP118630:588625-588924 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVDERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NDM6

References