Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2015412..2016061 Replicon chromosome
Accession NZ_CP118629
Organism Pantoea dispersa strain VWJL.P1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PWF83_RS09315 Protein ID WP_275028868.1
Coordinates 2015711..2016061 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NEP9
Locus tag PWF83_RS09310 Protein ID WP_021505978.1
Coordinates 2015412..2015711 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWF83_RS09290 (PWF83_09295) 2010933..2011688 + 756 WP_021505974.1 pyrroloquinoline-quinone synthase PqqC -
PWF83_RS09295 (PWF83_09300) 2011693..2011971 + 279 WP_021505975.1 pyrroloquinoline quinone biosynthesis peptide chaperone PqqD -
PWF83_RS09300 (PWF83_09305) 2011958..2013100 + 1143 WP_058758602.1 pyrroloquinoline quinone biosynthesis protein PqqE -
PWF83_RS09305 (PWF83_09310) 2013100..2015421 + 2322 WP_275028865.1 pyrroloquinoline quinone biosynthesis protein PqqF -
PWF83_RS09310 (PWF83_09315) 2015412..2015711 - 300 WP_021505978.1 helix-turn-helix transcriptional regulator Antitoxin
PWF83_RS09315 (PWF83_09320) 2015711..2016061 - 351 WP_275028868.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWF83_RS09320 (PWF83_09325) 2016271..2016621 + 351 WP_275028870.1 hypothetical protein -
PWF83_RS09325 (PWF83_09330) 2016671..2018674 + 2004 WP_275028872.1 protein-disulfide reductase DsbD family protein -
PWF83_RS09330 (PWF83_09335) 2018674..2019396 + 723 WP_031279069.1 DsbA family protein -
PWF83_RS09335 (PWF83_09340) 2019393..2019896 + 504 WP_104186604.1 thioredoxin domain-containing protein -
PWF83_RS09340 (PWF83_09345) 2020157..2020993 + 837 WP_275028875.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13372.63 Da        Isoelectric Point: 7.7777

>T273319 WP_275028868.1 NZ_CP118629:c2016061-2015711 [Pantoea dispersa]
MWEILTTDVFDDWFLAQNEGLREDMLAVMQILAEMGPKPGRPYVDTLKGCQFTNLKELRVQHAGMPVRAFFALDPVRRAI
VLCAGNKAGCQQKQFYRTMIRLAEAEYRKHLVHMEG

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11201.90 Da        Isoelectric Point: 10.0004

>AT273319 WP_021505978.1 NZ_CP118629:c2015711-2015412 [Pantoea dispersa]
MGTYKQLLAKQSPESQQRIAEKVEKLRQEIALSQLREELNLSQTELARTIGVSQPTLAKMENPENDPRLSTLKRYVAALG
GELRIDVKLPNGKHFAFQL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NEP9

References