Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2476005..2476711 Replicon chromosome
Accession NZ_CP118615
Organism Micromonospora sp. HUAS 3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PVK37_RS11425 Protein ID WP_275033831.1
Coordinates 2476005..2476400 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PVK37_RS11430 Protein ID WP_275033832.1
Coordinates 2476397..2476711 (+) Length 105 a.a.

Genomic Context

PVK37_RS11400PVK37_RS11405PVK37_RS11410PVK37_RS11415PVK37_RS11420PVK37_RS11425PVK37_RS11430PVK37_RS11435PVK37_RS11440PVK37_RS11445PVK37_RS11450PVK37_RS11455PVK37_RS11460
Location: 2471049..2471969 (921 bp)
Type: Others
Protein ID: WP_275033826.1
Location: 2472025..2472834 (810 bp)
Type: Others
Protein ID: WP_275033827.1
Location: 2472949..2474151 (1203 bp)
Type: Others
Protein ID: WP_275033828.1
Location: 2474148..2475158 (1011 bp)
Type: Others
Protein ID: WP_275033829.1
Location: 2475250..2475936 (687 bp)
Type: Others
Protein ID: WP_275033830.1
Location: 2476005..2476400 (396 bp)
Type: Toxin
Protein ID: WP_275033831.1
Location: 2476397..2476711 (315 bp)
Type: Antitoxin
Protein ID: WP_275033832.1
Location: 2476796..2476951 (156 bp)
Type: Others
Protein ID: WP_275033834.1
Location: 2477104..2477451 (348 bp)
Type: Others
Protein ID: WP_275035085.1
Location: 2477448..2478953 (1506 bp)
Type: Others
Protein ID: WP_275033835.1
Location: 2478996..2480324 (1329 bp)
Type: Others
Protein ID: WP_275035086.1
Location: 2480399..2480623 (225 bp)
Type: Others
Protein ID: WP_275033836.1
Location: 2480636..2481472 (837 bp)
Type: Others
Protein ID: WP_275033837.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PVK37_RS11400 (PVK37_11400)2471049..2471969+921WP_275033826.1ABC transporter permease-
PVK37_RS11405 (PVK37_11405)2472025..2472834+810WP_275033827.1ABC transporter permease-
PVK37_RS11410 (PVK37_11410)2472949..2474151+1203WP_275033828.1saccharopine dehydrogenase C-terminal domain-containing protein-
PVK37_RS11415 (PVK37_11415)2474148..2475158+1011WP_275033829.1agmatinase-
PVK37_RS11420 (PVK37_11420)2475250..2475936+687WP_275033830.1G5 domain-containing protein-
PVK37_RS11425 (PVK37_11425)2476005..2476400+396WP_275033831.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PVK37_RS11430 (PVK37_11430)2476397..2476711+315WP_275033832.1helix-turn-helix transcriptional regulatorAntitoxin
PVK37_RS11435 (PVK37_11435)2476796..2476951-156WP_275033834.1DUF433 domain-containing protein-
PVK37_RS11440 (PVK37_11440)2477104..2477451-348WP_275035085.1DUF779 domain-containing protein-
PVK37_RS11445 (PVK37_11445)2477448..2478953-1506WP_275033835.1aldehyde dehydrogenase family protein-
PVK37_RS11450 (PVK37_11450)2478996..2480324-1329WP_275035086.1transcriptional regulator-
PVK37_RS11455 (PVK37_11455)2480399..2480623-225WP_275033836.1DUF397 domain-containing protein-
PVK37_RS11460 (PVK37_11460)2480636..2481472-837WP_275033837.1helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-118)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-92)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14939.96 Da        Isoelectric Point: 10.7309

>T273315 WP_275033831.1 NZ_CP118615:2476005-2476400 [Micromonospora sp. HUAS 3]
VGTTGNRRWSVRVTGEVRQWLRDLRQADPSTYHSVSVAIDMLAEVGPALGRPLVDTLRGSQVSNLKELRPRSGRDVAVRV
LFVFDPWSQAVLLVTGNKAGNWTRWYDEHVPLAEKVYKTWLDQERERRGKG

Download         Length: 396 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11679.96 Da        Isoelectric Point: 4.3705

>AT273315 WP_275033832.1 NZ_CP118615:2476397-2476711 [Micromonospora sp. HUAS 3]
VTEFYDWEDVRAELADEDAAAQQAERARTEAWVSAFHLAEERKRLGLTQRQVAELMGVTPGRVSQIENGDLDVNEVATLS
RYAAALGARLRIIFDYGNDLRQIA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References