Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2476005..2476711 Replicon chromosome
Accession NZ_CP118615
Organism Micromonospora sp. HUAS 3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PVK37_RS11425 Protein ID WP_275033831.1
Coordinates 2476005..2476400 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PVK37_RS11430 Protein ID WP_275033832.1
Coordinates 2476397..2476711 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK37_RS11400 (PVK37_11400) 2471049..2471969 + 921 WP_275033826.1 ABC transporter permease -
PVK37_RS11405 (PVK37_11405) 2472025..2472834 + 810 WP_275033827.1 ABC transporter permease -
PVK37_RS11410 (PVK37_11410) 2472949..2474151 + 1203 WP_275033828.1 saccharopine dehydrogenase C-terminal domain-containing protein -
PVK37_RS11415 (PVK37_11415) 2474148..2475158 + 1011 WP_275033829.1 agmatinase -
PVK37_RS11420 (PVK37_11420) 2475250..2475936 + 687 WP_275033830.1 G5 domain-containing protein -
PVK37_RS11425 (PVK37_11425) 2476005..2476400 + 396 WP_275033831.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVK37_RS11430 (PVK37_11430) 2476397..2476711 + 315 WP_275033832.1 helix-turn-helix transcriptional regulator Antitoxin
PVK37_RS11435 (PVK37_11435) 2476796..2476951 - 156 WP_275033834.1 DUF433 domain-containing protein -
PVK37_RS11440 (PVK37_11440) 2477104..2477451 - 348 WP_275035085.1 DUF779 domain-containing protein -
PVK37_RS11445 (PVK37_11445) 2477448..2478953 - 1506 WP_275033835.1 aldehyde dehydrogenase family protein -
PVK37_RS11450 (PVK37_11450) 2478996..2480324 - 1329 WP_275035086.1 transcriptional regulator -
PVK37_RS11455 (PVK37_11455) 2480399..2480623 - 225 WP_275033836.1 DUF397 domain-containing protein -
PVK37_RS11460 (PVK37_11460) 2480636..2481472 - 837 WP_275033837.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-118)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-92)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14939.96 Da        Isoelectric Point: 10.7309

>T273315 WP_275033831.1 NZ_CP118615:2476005-2476400 [Micromonospora sp. HUAS 3]
VGTTGNRRWSVRVTGEVRQWLRDLRQADPSTYHSVSVAIDMLAEVGPALGRPLVDTLRGSQVSNLKELRPRSGRDVAVRV
LFVFDPWSQAVLLVTGNKAGNWTRWYDEHVPLAEKVYKTWLDQERERRGKG

Download         Length: 396 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11679.96 Da        Isoelectric Point: 4.3705

>AT273315 WP_275033832.1 NZ_CP118615:2476397-2476711 [Micromonospora sp. HUAS 3]
VTEFYDWEDVRAELADEDAAAQQAERARTEAWVSAFHLAEERKRLGLTQRQVAELMGVTPGRVSQIENGDLDVNEVATLS
RYAAALGARLRIIFDYGNDLRQIA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References