Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1491665..1492323 Replicon chromosome
Accession NZ_CP118614
Organism Nocardiopsis sp. DZFXJ 01

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PV789_RS06775 Protein ID WP_274976619.1
Coordinates 1491665..1492018 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag PV789_RS06780 Protein ID WP_274976620.1
Coordinates 1492018..1492323 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PV789_RS06745 (PV789_06745) 1488038..1488505 + 468 WP_274976616.1 DUF1232 domain-containing protein -
PV789_RS06750 (PV789_06750) 1488654..1488959 - 306 WP_047871987.1 30S ribosomal protein S14 -
PV789_RS06755 (PV789_06755) 1488959..1489195 - 237 WP_130396777.1 50S ribosomal protein L28 -
PV789_RS06760 (PV789_06760) 1489286..1490380 - 1095 WP_274978069.1 GTP-binding protein -
PV789_RS06765 (PV789_06765) 1490543..1490962 + 420 WP_274976617.1 VOC family protein -
PV789_RS06770 (PV789_06770) 1491029..1491316 - 288 WP_274976618.1 YciI family protein -
PV789_RS06775 (PV789_06775) 1491665..1492018 + 354 WP_274976619.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PV789_RS06780 (PV789_06780) 1492018..1492323 + 306 WP_274976620.1 XRE family transcriptional regulator Antitoxin
PV789_RS06785 (PV789_06785) 1492402..1492575 - 174 WP_212641121.1 hypothetical protein -
PV789_RS06790 (PV789_06790) 1492572..1494263 - 1692 WP_274976621.1 hypothetical protein -
PV789_RS06795 (PV789_06795) 1494404..1497178 - 2775 WP_274976622.1 GTPase-associated protein 1-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-84)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13190.00 Da        Isoelectric Point: 5.6716

>T273311 WP_274976619.1 NZ_CP118614:1491665-1492018 [Nocardiopsis sp. DZFXJ 01]
VWTIELGLVEPWLDQLDQSSYEQVIAALELLAETGPPLGRPLVDAVHGSRHRNMKELRPGSSGRSELRVLFAFDSARKAI
LLVAGDKSGNWNKWYRKNIPIADDLFDEHIEKLRGEA

Download         Length: 354 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11758.40 Da        Isoelectric Point: 8.0429

>AT273311 WP_274976620.1 NZ_CP118614:1492018-1492323 [Nocardiopsis sp. DZFXJ 01]
MGTSLHDMLAKRPVDREAVETRKRRMLDEVRAYHLRELRELSELTQVQLAERLNISQNRVSSIERGDIGRSQVETLRRYV
EALGGELRVEVEIGDQRCRIA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References