273285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4700835..4701437 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag OU688_RS22415 Protein ID WP_000897305.1
Coordinates 4701126..4701437 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OU688_RS22410 Protein ID WP_000356397.1
Coordinates 4700835..4701125 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS22385 (4696761) 4696761..4697663 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
OU688_RS22390 (4697660) 4697660..4698295 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
OU688_RS22395 (4698292) 4698292..4699221 + 930 WP_000027706.1 formate dehydrogenase accessory protein FdhE -
OU688_RS22400 (4699551) 4699551..4699793 - 243 WP_174785388.1 CopG family transcriptional regulator -
OU688_RS22405 (4700012) 4700012..4700230 - 219 WP_001295676.1 CopG family transcriptional regulator -
OU688_RS22410 (4700835) 4700835..4701125 - 291 WP_000356397.1 NadS family protein Antitoxin
OU688_RS22415 (4701126) 4701126..4701437 - 312 WP_000897305.1 hypothetical protein Toxin
OU688_RS22420 (4701666) 4701666..4702574 + 909 WP_001162704.1 alpha/beta hydrolase -
OU688_RS22425 (4702638) 4702638..4703579 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
OU688_RS22430 (4703624) 4703624..4704061 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
OU688_RS22435 (4704058) 4704058..4704930 - 873 WP_000920762.1 virulence factor BrkB family protein -
OU688_RS22440 (4704924) 4704924..4705523 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T273285 WP_000897305.1 NZ_CP118601:c4701437-4701126 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT273285 WP_000356397.1 NZ_CP118601:c4701125-4700835 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References