Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3860894..3861435 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag OU688_RS18575 Protein ID WP_000615976.1
Coordinates 3861157..3861435 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag OU688_RS18570 Protein ID WP_000729704.1
Coordinates 3860894..3861154 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS18545 (3856677) 3856677..3857462 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
OU688_RS18550 (3857434) 3857434..3859146 + 1713 Protein_3633 flagellar biosynthesis protein FlhA -
OU688_RS18555 (3859251) 3859251..3859529 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
OU688_RS18560 (3859522) 3859522..3859878 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
OU688_RS18565 (3859935) 3859935..3860708 - 774 WP_000543899.1 C40 family peptidase -
OU688_RS18570 (3860894) 3860894..3861154 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OU688_RS18575 (3861157) 3861157..3861435 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OU688_RS18580 (3861591) 3861591..3862331 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OU688_RS18585 (3862302) 3862302..3863069 - 768 WP_000333380.1 class II glutamine amidotransferase -
OU688_RS18590 (3863275) 3863275..3863853 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T273283 WP_000615976.1 NZ_CP118601:3861157-3861435 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT273283 WP_000729704.1 NZ_CP118601:3860894-3861154 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References