Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4685517..4686119 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name higB Uniprot ID A0A155DUZ6
Locus tag PXV21_RS22405 Protein ID WP_022649837.1
Coordinates 4685808..4686119 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PXV21_RS22400 Protein ID WP_022649836.1
Coordinates 4685517..4685807 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS22385 (PXV21_22385) 4683015..4683917 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
PXV21_RS22390 (PXV21_22390) 4683914..4684549 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
PXV21_RS22395 (PXV21_22395) 4684546..4685475 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
PXV21_RS22400 (PXV21_22400) 4685517..4685807 - 291 WP_022649836.1 NadS family protein Antitoxin
PXV21_RS22405 (PXV21_22405) 4685808..4686119 - 312 WP_022649837.1 hypothetical protein Toxin
PXV21_RS22410 (PXV21_22410) 4686268..4687209 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
PXV21_RS22415 (PXV21_22415) 4687254..4687691 - 438 WP_022649839.1 D-aminoacyl-tRNA deacylase -
PXV21_RS22420 (PXV21_22420) 4687688..4688569 - 882 WP_022649840.1 virulence factor BrkB family protein -
PXV21_RS22425 (PXV21_22425) 4688563..4689162 - 600 WP_022649841.1 glucose-1-phosphatase -
PXV21_RS22430 (PXV21_22430) 4689281..4690081 - 801 WP_022649842.1 DeoR/GlpR family DNA-binding transcription regulator -
PXV21_RS22435 (PXV21_22435) 4690116..4691012 - 897 WP_022649843.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12148.13 Da        Isoelectric Point: 9.4455

>T273241 WP_022649837.1 NZ_CP118567:c4686119-4685808 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10699.21 Da        Isoelectric Point: 10.5888

>AT273241 WP_022649836.1 NZ_CP118567:c4685807-4685517 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155DUZ6

Antitoxin

Source ID Structure

References