Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4459660..4460262 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PWA52_RS21625 Protein ID WP_001159635.1
Coordinates 4459951..4460262 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PWA52_RS21620 Protein ID WP_000362050.1
Coordinates 4459660..4459950 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS21605 (4457156) 4457156..4458058 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PWA52_RS21610 (4458055) 4458055..4458687 + 633 WP_020937226.1 formate dehydrogenase cytochrome b556 subunit -
PWA52_RS21615 (4458684) 4458684..4459613 + 930 WP_000027739.1 formate dehydrogenase accessory protein FdhE -
PWA52_RS21620 (4459660) 4459660..4459950 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PWA52_RS21625 (4459951) 4459951..4460262 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PWA52_RS21630 (4460480) 4460480..4461409 + 930 WP_000171444.1 alpha/beta hydrolase -
PWA52_RS21635 (4461495) 4461495..4461806 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
PWA52_RS21640 (4461803) 4461803..4462249 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PWA52_RS21645 (4462264) 4462264..4463205 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PWA52_RS21650 (4463250) 4463250..4463687 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
PWA52_RS21655 (4463684) 4463684..4464556 - 873 WP_000921423.1 virulence factor BrkB family protein -
PWA52_RS21660 (4464550) 4464550..4465149 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T273209 WP_001159635.1 NZ_CP118542:c4460262-4459951 [Salmonella sp. CVCC 1806]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT273209 WP_000362050.1 NZ_CP118542:c4459950-4459660 [Salmonella sp. CVCC 1806]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References